Presenters: Pourash Patel and Akhilesh Mishra

In Silico medicine leverages computational models and simulations to revolutionize the development of medical devices and pharmaceuticals. These powerful simulation models are designed to accurately replicate the complex anatomy, physiology, and biological processes of the human body.

In this hands-on workshop, you will gain practical experience in this cutting-edge field. We will teach you step-by-step how to build a high-fidelity electrophysiology heart model, a functional physiological model critical for cardiac device development. You will then learn how to simulate and analyze these sophisticated models, understanding their role as vital testbeds for medical device design, verification, and validation.

Highlights:

• Build and refine high-fidelity simulation models of human physiological systems, with a specific focus on cardiac electrophysiology.
• Learn the hybrid automata approach for modeling differential equations with state machines to represent conduction pathways and cardiac cells.
• Learn to parameterize models for simulating a variety of diseased states – e.g., generate EGMs and ECGs by simulating regional ischemia.
• Explore real-time device validation using Hardware-In-the-Loop (HIL) techniques with human simulation models, significantly lowering the burden of traditional clinical trials.
• Understand FDA certification guidelines pertinent to In Silico models.

Hardware and Software Requirements:

To participate in the workshop, you will need:

• A laptop
• Google Chrome browser
• A MathWorks account

You will be provided with a temporary MATLAB workshop license that grants access to all products used in the workshop, as well as the necessary exercise files.